Calcineurin inhibitors and arterial hypertension in recipients of solid organs
نویسندگان
چکیده
منابع مشابه
How calcineurin inhibitors cause hypertension.
Calcineurin is a calcium-dependent serine–threonine protein phosphatase. Calcineurin activates the nuclear factor of activated T-cells cytoplasmic (NFAT)c, a transcription factor, by dephosphorylating the protein. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T-...
متن کاملPathophysiological mechanisms of calcineurin inhibitor-induced nephrotoxicity and arterial hypertension.
Solid organ transplantation is an established treatment modality in patients with end-stage organ damage in cases where other therapeutic options fail. The long-term outcomes of solid organ transplant recipients have improved considerably since the introduction of the first calcineurin inhibitor (CNI) - cyclosporine. In 1984, the potent immunosuppressive properties of another CNI, tacrolimus, w...
متن کاملEffect of calcineurin inhibitors in the outcome of liver transplantation in hepatitis C virus-positive recipients.
BACKGROUND There is a paucity of good studies evaluating the impact of calcineurin inhibitors on posttransplantation outcome in hepatitis C virus (HCV)-infected liver transplant (LT) recipients. METHODS We sought to determine whether there are differences on posttransplantation survival and histologic recurrence in HCV-LT recipients based on initial immunosuppression (IS) by conducting a pros...
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Pulmonary arterial hypertension (PAH) is a progressive disease with high morbidity and mortality rates. Research has shown that PAH has a prevalence rate of 10-79% in thalassemia major patients. This cross-sectional study was carried out in 2014 to determine the prevalence and risk factors of PAH in all thalassemia major patients of over 18 years of age in Ilam, Iran. A cardiologist measured sy...
متن کاملDetermination of Calcineurin Inhibitors in Dried Blood Spots from Kidney Transplant Recipients
Background: Determination of cyclosporine A (CsA) and tacrolimus (Tac) in dried blood spots (DBS) could enable drug monitoring in transplanted patients without the necessity of having to take venous blood samples. Therefore, we have developed a method for quantitative determination of calcineurin inhibitors (CNI) by liquid-chromatography-tandem mass spectrometry (LCMS). Methods: In a study with...
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ژورنال
عنوان ژورنال: Systemic Hypertension
سال: 2017
ISSN: 2542-2189,2075-082X
DOI: 10.26442/sg29591